GEO series
Single-cell multiomic analysis identifies macrophage subpopulations in promoting cardiac repair
GSE225615
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
48 samples
2024/09/06
GPL24247
Summary
Our study comprehensively investigated the epigenetic features of cardiac F4/80+CD45+ macrophages at 3 and 7 days after P1 and P10 MI at infarct, border, and remote zones of mouse hearts (IZ, BZ, and RZ) through single cell H3K27ac ChIP-seq. we identified 9 subclusters and analyzed their potential functions, cluster-specific enhancer features, and enrichment of cell-type specific transcription factors. Surprisingly, we found intracluster epigenetic heterogeneity exists with biological functions. Moreover, we identified two MI-responsive lineages and targeted one inflammatory lineage exhibiting obvious pre-regenerative function.
Download
NCBI GEO page ↗
Paper (PMID 39190625) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse ChIP / ATAC / CUT&Tag datasets →
Similar datasets
- GSE339012 Mega-Enhancers Compartmentalize Transcriptionally Active Long Genes in the Brain [ChIP-Seq] 22 samples
- GSE328495 Gene expression + ATAC profiling of trisomic hippocampal neurons upon SAHA treatment [ATAC-seq] 16 samples
- GSE249984 Androgen receptor action in mouse granulosa cells in response to LH surge 14 samples
- GSE324864 HP1B and H3K9me3 Regulate Olfactory Receptor Choice and 2 Transcriptional Identity [ChIP-seq] 28 samples
- GSE306458 ACVR1-mediated glycolytic reprogramming promotes histone lactylation and neuronal pyroptosis in neuropathic pain {ChIP-seq] 12 samples
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples
- GSE292285 Depletion of lamin-associated polypeptide 2 alpha leads to chromatin reorganization and redistribution of A-type lamins to open genomic regions [ChIP-seq] 22 samples
- GSE318435 ATAC-seq of the granulopoiesis lineage from different organs 34 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.