Blood-based Genomic and Cellular Determinants of Response to Neoadjuvant PD-1 Blockade in Patients with Non-Small-Cell Lung Cancer
RNA-seq (gene expression) · human · 43 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 43 samples: 21 × post-treatment blood vs 17 × pre-treatment blood vs 5 × Normal PBMCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Blood-based molecular and cellular biomarkers of early response to neoadjuvant PD-1 blockade in patients with non-small cell lung cancerCancer cell international · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE225620_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA936827 and SRA study SRP423461. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 43 samples.
How we read this: 3 replicated groups read from 43 sample titles; they account for 43 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7051330 pre-treatment blood1 pre-treatment blood
- GSM7051331 post-treatment blood1 post-treatment blood
- GSM7051332 post-treatment blood2 post-treatment blood
- GSM7051333 post-treatment blood3 post-treatment blood
- GSM7051334 post-treatment blood4 post-treatment blood
- GSM7051335 pre-treatment blood2 pre-treatment blood
- GSM7051336 pre-treatment blood3 pre-treatment blood
- GSM7051337 post-treatment blood5 post-treatment blood
- GSM7051338 pre-treatment blood4 pre-treatment blood
- GSM7051339 post-treatment blood6 post-treatment blood
- GSM7051340 post-treatment blood7 post-treatment blood
- GSM7051341 pre-treatment blood5 pre-treatment blood
- GSM7051342 post-treatment blood8 post-treatment blood
- GSM7051343 post-treatment blood9 post-treatment blood
- GSM7051344 pre-treatment blood6 pre-treatment blood
- GSM7051345 post-treatment blood10 post-treatment blood
- GSM7051346 pre-treatment blood7 pre-treatment blood
- GSM7051347 post-treatment blood11 post-treatment blood
- GSM7051348 pre-treatment blood8 pre-treatment blood
- GSM7051349 post-treatment blood12 post-treatment blood
- GSM7051350 pre-treatment blood9 pre-treatment blood
- GSM7051351 post-treatment blood13 post-treatment blood
- GSM7051352 pre-treatment blood10 pre-treatment blood
- GSM7051353 post-treatment blood14 post-treatment blood
- GSM7051354 pre-treatment blood11 pre-treatment blood
- GSM7051355 post-treatment blood15 post-treatment blood
- GSM7051356 pre-treatment blood12 pre-treatment blood
- GSM7051357 post-treatment blood16 post-treatment blood
- GSM7051358 pre-treatment blood13 pre-treatment blood
- GSM7051359 post-treatment blood17 post-treatment blood
- GSM7051360 pre-treatment blood14 pre-treatment blood
- GSM7051361 post-treatment blood18 post-treatment blood
- GSM7051362 pre-treatment blood15 pre-treatment blood
- GSM7051363 post-treatment blood19 post-treatment blood
- GSM7051364 pre-treatment blood16 pre-treatment blood
- GSM7051365 post-treatment blood20 post-treatment blood
- GSM7051366 pre-treatment blood17 pre-treatment blood
- GSM7051367 post-treatment blood21 post-treatment blood
- GSM7051368 Normal PBMC1 Normal PBMC
- GSM7051369 Normal PBMC2 Normal PBMC
+ 3 more — browse all 43 samples with per-sample file links →
- GSE127465 Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species 40 samples same disease briefing · shares lung
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples same disease briefing · shares lung
- GSE241518 High-throughout sequencing of colorectal cancer and non-small cell lung cancer cells treated actived compound YHM18 4 samples same disease briefing · shares lung
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples same disease briefing · shares lung
- GSE17958 Affymetrix SNP array data for 47 lung squamous cell carcinoma and 40 esophageal squamous cell carcinoma samples. 87 samples same disease briefing · shares lung
- GSE114761 Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Signature Predicts Metastasis-Free Survival in Non-Small Cell Lung Cancer. 42 samples same disease briefing · shares lung
- GSE104244 Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents 33 samples same disease briefing · shares lung
- GSE117570 Reprogramming of Tumor-infiltrating Immune Cells in Early Stage of NSCLC 8 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.