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Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expression

GSE225952 Mus musculus (mouse) Non-coding RNA profiling 56 samples Submitted 2026/05/15 Platform GPL17021
At a glance

Non-coding RNA profiling · mouse · 56 samples

What it is
Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
Organism
Mus musculus (mouse)
Samples
56 samples: 8 conditions, mostly with about 8 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expressionJournal of hypertension · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Endothelin-1 overexpression in mice increases vascular Vegfa164 and Vegfa188 alternative splice isoforms via enhanced Khdrbs3 expression
Berillo O, Coelho SC, Ferreira NS et al. · Journal of hypertension 2026 · PMID 42253124 · doi:10.1097/HJH.0000000000004363
This dataset
Open GSE225952 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE225952_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

Also filed as BioProject PRJNA938094 and SRA study SRP423988. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 42253124) ↗
Study design
8 conditions, mostly with about 8 replicates each
mesenteric artery ieCre Short term ×8 mesenteric artery ieCre Long term ×8 mesenteric artery ieET-1 Short term ×8 mesenteric artery ieET-1 Long term ×8 mesenteric artery ieCre Short term ID ×6 mesenteric artery ieCre Long term ID ×6 mesenteric artery ieET-1 Short term ID ×6 mesenteric artery ieET-1 Long term ID ×6

Supports a between-group comparison across 56 samples.

How we read this: 8 replicated groups read from 56 sample titles; they account for 56 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 16 more — browse all 56 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.