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Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [NTD-chIP-seq]

GSE225997 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/03/12 Platform GPL16791
Summary
To investigate changes in RNAPII distribution in response to SF3B1 mutations, we peformed ChIP-seq using antibody against N-terminal domain of RNAPII (Pan-Pol2) in K562 cells (wild type and SF3B1K700E mutant) at 4 days after mutant allele expression We then performed coverage plot analysis using data obtained from ChIP-seq to investigate RNAPII distribution changes
Published in
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
Boddu PC, Gupta AK, Roy R et al. · Molecular cell 2024 · PMID 38521065 · doi:10.1016/j.molcel.2024.02.032
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Also filed as BioProject PRJNA939538 and SRA study SRP425044. Searching any of these in the dataset finder brings you back here.

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