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Stiffness Assisted Cell-Matrix Remodeling Trigger Mechanotransduction Regulatory Programs to Induce Stem Cell Differentiation

GSE226411 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/01 Platform GPL23227
Summary
The interplay of transcription and epigenetics in response to biophysical factors is important in the design of engineered matrix platforms that seek to direct cellular fate. We present a nanoparticle crosslinker to reinforce hydrogels and study the impact on hMSC transcription through RNA-seq. The study provides insight into how environmental stiffness drives global intracellular signaling through PI3AKT transction and chromatin remodeling to enable YAP/TAZ activity.
Published in
Stiffness assisted cell-matrix remodeling trigger 3D mechanotransduction regulatory programs
Kersey AL, Cheng DY, Deo KA et al. · Biomaterials 2024 · PMID 38335719 · doi:10.1016/j.biomaterials.2024.122473
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Also filed as BioProject PRJNA940143 and SRA study SRP425182. Searching any of these in the dataset finder brings you back here.

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