Distinct molecular features in early-onset lung adenocarcinoma
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 14 samples: 7 × early-onset LUAD vs 7 × late-onset LUADGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Comprehensive characterization of early-onset lung cancer, in Chinese young adultsNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE226481_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA940414 and SRA study SRP425407. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 2 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7076392 early-onset LUAD 1 early-onset LUAD
- GSM7076393 early-onset LUAD 2 early-onset LUAD
- GSM7076394 early-onset LUAD 3 early-onset LUAD
- GSM7076395 early-onset LUAD 4 early-onset LUAD
- GSM7076396 early-onset LUAD 5 early-onset LUAD
- GSM7076397 early-onset LUAD 6 early-onset LUAD
- GSM7076398 early-onset LUAD 7 early-onset LUAD
- GSM7076399 late-onset LUAD 1 late-onset LUAD
- GSM7076400 late-onset LUAD 2 late-onset LUAD
- GSM7076401 late-onset LUAD 3 late-onset LUAD
- GSM7076402 late-onset LUAD 4 late-onset LUAD
- GSM7076403 late-onset LUAD 5 late-onset LUAD
- GSM7076404 late-onset LUAD 6 late-onset LUAD
- GSM7076405 late-onset LUAD 7 late-onset LUAD
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- GSE114761 Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Signature Predicts Metastasis-Free Survival in Non-Small Cell Lung Cancer. 42 samples same disease briefing · shares lung
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.