The effect of the STING antagonist on the gene expression changes in the kidney of Trex1 -/- mice
RNA-seq (gene expression) · mouse · 9 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 7 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrative Analyses Identify a cGAS-STING Pathway-Driven Signature With Context-Dependent Roles in Systemic Lupus ErythematosusAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE226594_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA940751. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 9 sample titles: 7 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7079936 KO_1_R1.fq.gz
- GSM7079937 KO_2_R1.fq.gz
- GSM7079938 KO_3_R1.fq.gz
- GSM7079939 KO_SN011_1
- GSM7079940 KO_SN011_2
- GSM7079941 KO_SN011_3
- GSM7079942 WT_1_R1.fq.gz
- GSM7079943 WT_2_R1.fq.gz
- GSM7079944 WT_3_R1.fq.gz
- GSE281365 Combustion products of burn pit constituents induce more changes in murine lungs with pre-existing asthma than naïve lungs 27 samples shares sting, changes
- GSE186037 Gene expression changes in mouse kidney cancer cells (RENCA) after anti-PD-L1 resistance 12 samples shares changes, kidney
- GSE275998 On the way to elucidate the effects of cannabidiol (CBD) on living organisms - assessment of changes in the global transcription profile of kidney in a mouse model 12 samples shares changes, kidney
- GSE307122 Urinary Clusterin as a Biomarker of Human Kidney Disease Progression and Response to the Endothelin Receptor Antagonist Atrasentan: An Exploratory Analysis from the SONAR Trail 17 samples shares antagonist, kidney
- GSE290224 Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle 96 samples shares sting
- GSE240884 The gene expression profiling of 3'2'-cCAMP signaling and 2'3'-cGAMP signaling in the BMDMs of WT and STING deficienc mice 24 samples shares sting
- GSE271744 Bulk RNAseq of mononucleated cells isolated from resting and regenerating adult and aged skeletal mouse muscle 107 samples shares sting
- GSE331176 Phagosome-mediated activation of STING by purine and pyrimidine-based bacterial cyclic dinucleotides 380 samples shares sting
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.