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Spatial profiling of human immune cells in sarcoidosis

GSE227041 Homo sapiens Expression profiling by high throughput sequencing; Other 9 samples Submitted 2024/09/13 Platform GPL16791
Summary
Sarcoidosis is a multiorgan inflammatory disease that is characterized by tissue granulomas and remains so challenging for clinicians to diagnose that it has been called “the great imitator”. Here, by performing single-cell sequencing and spatial transcriptomics on skin granulomas from sarcoid and non-sarcoid patients, we discovered increased recruitment of innate lymphoid cells in granulomas. Sarcoid-associated cells exhibited increased cell migration compared to healthy individuals. Importantly, granuloma formation was attenuated in mice genetically lacking these cells or treated with a pharmacologic inhibitor.
Published in
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases
Sati S, Huang J, Kersh AE et al. · The Journal of clinical investigation 2024 · PMID 39225100 · doi:10.1172/JCI178711
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Direct links to NCBI, no account and no request form: the whole study as GSE227041_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA942949 and SRA study SRP426468. Searching any of these in the dataset finder brings you back here.

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