GEO series
IL-21 induces antitumor response in NK cells via CEBPD
GSE227098
Homo sapiens
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
60 samples
2024/07/09
GPL24676
Summary
NK cells engineered to express IL-21 (IL-21 NK) acquire strong antitumor activity, with the ability to respond to glioblastoma (GBM) rechallenge in vitro and in vivo. IL-21 NK cells have a unique signature of chromatin accessibility, with CCAAT/Enhancer-Binding Protein (C/EBP), especially CEBPD, serving as key transcription factors regulating their memory response.
Download
NCBI GEO page ↗
Paper (PMID 39137729) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE300595 Multiomic sequencing identifies myeloid cell associations with neoadjuvant chemotherapy treatment response in pancreatic adenocarcinoma (PDAC) 24 samples
- GSE335464 Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals [single cell] 28 samples
- GSE307120 Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma 21 samples
- GSE263717 Epigenomic profiles of SLE resting and transitional B cells 150 samples
- GSE233321 Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures 118 samples
- GSE283005 Distinct differentiation trajectories leave lasting impacts on gene regulation and function of V2a neurons 60 samples
- GSE342612 Transcriptomic and H3K27ac chromatin responses of human microglia to acute PFOS exposure and recovery 36 samples
- GSE222948 Early activity of GATA3 mediates patterning and lineage specification in human gastrulation 69 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.