GEO series
PGE2 effect on unstimulated and exhausted human CD8+ T-cells
GSE227316
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2024/03/08
GPL20301
Summary
Prostaglandin E2 (PGE2) is overexpressed in many tumors and plays an important role in suppressing T-cell function. In this study, we investigated the effect of PGE2 in human T-cells. Importantly, PGE2 caused profound transcriptomic changes both in unstimulated and exhausted T-cells with many genes and pathways altered including T-cell lipid metabolism. Our study suggests that PGE2-induced metabolic reprogramming is detrimental to dysfunctional T-cells and TIL, and its manipulation could be used to dampen the immunosuppressive effects of PGE2.
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Paper (PMID 38658764) ↗
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