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An integrated multi-omics and network analysis of neutrophil differentiation from early- to late-stage [ATAC-Seq]

GSE227543 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/11/24 Platform GPL20795
Summary
The goal of this study is to study the gene regulation mechanism during ATRA-induced HL-60 cell neutrophil differentiation especially in the early time-point. We demonstrated the striking early changes event that trigger the whole differentiation process. We also identified the pioneer TFs (Transcription factors) that ignite the differentiation process with the corresponding TF correlation networks.
Published in
An integrated multi-omics and network analysis of neutrophil differentiation from initial- to late-stage
Chen Q, Yang T, Hou Y et al. · Genome biology 2026 · PMID 41618446 · doi:10.1186/s13059-025-03902-1
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Also filed as BioProject PRJNA945477 and SRA study SRP427711. Searching any of these in the dataset finder brings you back here.

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