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Effect of TDP-43 and FUS silencing on gene expression of inmortalised human myoblast 8220 cell line

GSE227573 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/25 Platform GPL30173
Summary
To investigate the effects on human muscle precursor cells of a loss of function of Mendelian genes related to familial ALS, such as TARDBP (TDP-43) or FUS, we established human inmortalised myoblast cell lines in which each target gene has been transiently knocked down (KD) by shRNA.
Published in
Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis
Zufiría M, Pikatza-Menoio O, Garciandia-Arcelus M et al. · Acta neuropathologica 2024 · PMID 39283487 · doi:10.1007/s00401-024-02794-y
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Also filed as BioProject PRJNA945845 and SRA study SRP427811. Searching any of these in the dataset finder brings you back here.

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