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A single cell RNA-Seq 5’ study of splenic marginal zone lymphomas (SMZL) and spleen healthy donors

GSE227833 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/09/17 Platform GPL21697
Summary
Purpose: Single cell RNA-Seq was used to characterize in depth splenic samples obtained from splenic marginal zone lymphomas Methods: 3 frozen samples of spleen and blood from SMZL patients, and healthy donors were selected and thawed for performing a 10X genomics single cell RNA-Sequencing 5' assay. Results: Tumor cells formed mainly patient specific-B cell clusters, while T-cells from the 3 patients and healthy donors clustered together. Conclusion: Single RNA-Seq unveils inter- and intra-patient heterogeneity.
Published in
Integrated spatial and multimodal single-cell transcriptomics reveal patient-dependent cell heterogeneity in splenic marginal zone lymphoma
Cerapio JP, Gravelle P, Quillet-Mary A et al. · The Journal of pathology 2024 · PMID 38828498 · doi:10.1002/path.6296
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Also filed as BioProject PRJNA947155 and SRA study SRP428458. Searching any of these in the dataset finder brings you back here.

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