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A spatial transcriptomics study of splenic marginal zone lymphomas (SMZL) and spleen healthy donor

GSE228056 Homo sapiens Expression profiling by high throughput sequencing; Other 4 samples Submitted 2024/09/17 Platform GPL21697
Summary
Purpose: Spatial transcriptomics was used to characterize in depth splenic samples obtained from splenic marginal zone lymphomas Methods: 4 frozen samples of spleen from SMZL patients, and 1 healthy donor were selected and thawed for performing a 10X genomics Visium Spatial assay. Results: Tumor cells formed mainly patient specific-B cell clusters, while T-cells from the 3 patients and healthy donors clustered together. Conclusion: Single RNA-Seq unveils inter- and intra-patient heterogeneity.
Published in
Integrated spatial and multimodal single-cell transcriptomics reveal patient-dependent cell heterogeneity in splenic marginal zone lymphoma
Cerapio JP, Gravelle P, Quillet-Mary A et al. · The Journal of pathology 2024 · PMID 38828498 · doi:10.1002/path.6296
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Direct links to NCBI, no account and no request form: the whole study as GSE228056_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA947959 and SRA study SRP428931. Searching any of these in the dataset finder brings you back here.

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