Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × MDA-MB-231_DMSO vs 3 × MDA-MB-231_Ponatinib vs 3 × 4T1_DMSO vs 3 × 4T1_PonatinibGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Gene Signature-Based Drug Screening Reveals Ponatinib Enhances Immunotherapy Efficacy in Triple-Negative Breast Cancer by Reversing MDSC-Mediated Immunosuppressive Tumor MicroenvironmentResearch (Washington, D.C.) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE228550_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA950332 and SRA study SRP430118. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7123878 MDA-MB-231_DMSO_rep1 MDA-MB-231_DMSO
- GSM7123879 MDA-MB-231_DMSO_rep2 MDA-MB-231_DMSO
- GSM7123880 MDA-MB-231_DMSO_rep3 MDA-MB-231_DMSO
- GSM7123881 MDA-MB-231_Ponatinib_rep1 MDA-MB-231_Ponatinib
- GSM7123882 MDA-MB-231_Ponatinib_rep2 MDA-MB-231_Ponatinib
- GSM7123883 MDA-MB-231_Ponatinib_rep3 MDA-MB-231_Ponatinib
- GSM7123884 4T1_DMSO_rep1 4T1_DMSO
- GSM7123885 4T1_DMSO_rep2 4T1_DMSO
- GSM7123886 4T1_DMSO_rep3 4T1_DMSO
- GSM7123887 4T1_Ponatinib_rep1 4T1_Ponatinib
- GSM7123888 4T1_Ponatinib_rep2 4T1_Ponatinib
- GSM7123889 4T1_Ponatinib_rep3 4T1_Ponatinib
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- GSE324505 Cross-Species Transcriptomic Integration Reveals a Conserved, MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Driving Immunosuppression in Glioma 12 samples shares immunosuppression, mediated
- GSE307471 Intratumoral bacteria are immunosuppressive and promote immunotherapy resistance in head and neck squamous cell carcinoma 33 samples shares immunotherapy
- GSE292179 Priming with DNMT inhibitors potentiates PD-1 immunotherapy by triggering viral mimicry in relapsed/refractory NK/T-cell lymphoma 14 samples shares immunotherapy
- GSE303870 A tumor-associated macrophage-targeted immunocytokine leveraging T and NK cell synergy for potent cancer immunotherapy 223 samples shares immunotherapy
- GSE314854 Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy 102 samples shares immunotherapy
- GSE295309 Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity 39 samples shares immunotherapy
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.