GEO series
Reversing myeloid-derived suppressor cells mediated immunosuppression via p38α inhibition enhances immunotherapy efficacy
GSE228550
Mus musculus; Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/12/02
GPL24247GPL24676
Summary
By combining the tumor immunological phenotype (TIP) gene signature and high throughput sequencing based high throughput screening (HTS2), we identified that ponatinib significantly inhibits the expression of “cold” tumor associated chemokines CXCL1 and CXCL2 in cancer cells. To investigate how ponatinib regulates the expression of “cold”-tumor related genes CXCL1 and CXCL2, we conducted RNA-seq study to examine transcriptome-wide effects of ponatinib with both MDA-MB-231 cells and 4T1 cells.
Download
NCBI GEO page ↗
Paper (PMID 41079672) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
RNA-seq datasets →
Similar datasets
- GSE319021 Viral entry defines the hepatitis E virus species barrier in murine hepatocytes 60 samples
- GSE293412 TWIST1 drives endothelial-to-mesenchymal-transition to stabilize atherosclerotic plaques 29 samples
- GSE289625 RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity [RNAseq] 28 samples
- GSE277025 Inhaled Xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy 192 samples
- GSE293117 GPR34 loss-of-function rescues TREM2 metabolic dysfunction and promotes responsive microglial states 56 samples
- GSE335842 Single-Cell RNA sequencing reveals clonally-expanded CD4+ tissue-resident memory T cells in Histidyl-tRNA Synthetase-induced myositis 38 samples
- GSE331030 Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity [sc-lentiMPRA 2] 66 samples
- GSE294355 Dual function of DOT1L suppresses tumor intrinsic immunogenicity in Hepatocellular carcinoma [RNA-seq] 36 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.