← BioTransfer GEO Dataset Finder
GEO series

Gene expression profiling data following overexpression of TRIM8 in lung cancer cell lines (A549, CL1-0, H358)

GSE229282 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/12 Platform GPL24676
Summary
Lung cancer is the cancer with the highest mortality rate in the world. Ubiquitination is a post-translational modification that is widely present in cells to regulate the level of intracellular proteins, and is closely related to cancer progression. TRIM8 as an E3 ligase is one of the members of ubiquitination. In order to characterized the function of TRIM8 in lung adenocarcinoma, we overexpressed TRIM8 in different p53-type cell lines (A549, CL1-0 and H358)
Published in
E3 ligase TRIM8 suppresses lung cancer metastasis by targeting MYOF degradation through K48-linked polyubiquitination
Wei CH, Weng CW, Wu CY et al. · Cell death & disease 2025 · PMID 39934162 · doi:10.1038/s41419-025-07421-6
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE229282_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA953958 and SRA study SRP431739. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.