Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × P310s,Sting-WT, vs 5 × P310s,Sting-KO,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathwayNeuroscience · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE229411_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA954379 and SRA study SRP432005. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7162984 P310s,Sting-WT, replicate 1 P310s,Sting-WT,
- GSM7162985 P310s,Sting-WT, replicate 2 P310s,Sting-WT,
- GSM7162986 P310s,Sting-WT, replicate 3 P310s,Sting-WT,
- GSM7162987 P310s,Sting-WT, replicate 4 P310s,Sting-WT,
- GSM7162988 P310s,Sting-WT, replicate 5 P310s,Sting-WT,
- GSM7162989 P310s,Sting-KO, replicate 1 P310s,Sting-KO,
- GSM7162990 P310s,Sting-KO, replicate 2 P310s,Sting-KO,
- GSM7162991 P310s,Sting-KO, replicate 3 P310s,Sting-KO,
- GSM7162992 P310s,Sting-KO, replicate 4 P310s,Sting-KO,
- GSM7162993 P310s,Sting-KO, replicate 5 P310s,Sting-KO,
- GSE264504 Microbial infection instigates tau-related pathology in Alzheimer's disease via activating neuroimmune cGAS-STING pathway 10 samples shares tau-related, neuroimmune, instigates, activating, cgas-sting, microbial, pathology, alzheimer
- GSE241587 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin cardiomyopathy mice [sci-RNA-seq] 96 samples shares activating, cgas-sting
- GSE241577 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice [mRNA-seq] 46 samples shares activating, cgas-sting
- GSE274800 Probiotic Bacteria-Released Extracellular Vesicles Enhance Macrophage Phagocytosis in Polymicrobial Sepsis Through Activating the FPR1/2 Pathway 12 samples shares activating, microbial
- GSE272313 The autophagy-targeting compound V46 enhances antimicrobial responses to Mycobacteroides abscessus by activating transcription factor EB 6 samples shares activating, microbial
- GSE241590 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice 163 samples shares activating, cgas-sting
- GSE253444 Combining TIGIT blockade with MDSC inhibition hinders breast cancer bone metastasis by activating anti-tumor immunity 55 samples shares activating
- GSE253810 Ubiquitin-activating enzyme mediates immune escape via suppressing interferon signaling [bulk RNA-seq] 51 samples shares activating
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.