GEO series
Evaluating the effects of PTEN loss-driven cell transformation
GSE229554
Homo sapiens
Expression profiling by high throughput sequencing
13 samples
2024/04/01
GPL24676
Summary
We developed a unique in vitro transformation model utilizing PTEN CRISPR in the MCF10A human mammary epithelial cell line to study PTEN loss-induced transformation and profiled genome-wide expression in these cells to understand how PTEN loss alters the transcription landscape. We also examined changes in gene expression following inhibition of the p110b catalytic subunit of PI3 kinase, which is activated in the transformed cells. In addition, we profiled gene expression in MCF10A cells ectopically expressing PD-L1 (CD274), which is suppressed in cells harboring PTEN CRISPR.
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Paper (PMID 41000885) ↗
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