Effect of pituitary stalk electrical lesion (PEL) and growth hormone (GH) treatment on hypothalamic and hippocampal gene expression
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Oxytocin attenuates hypothalamic injury-induced cognitive dysfunction by inhibiting hippocampal ERK signaling and Aβ depositionTranslational psychiatry · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE229838_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA956295 and SRA study SRP432888. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7178949 HIP-PEL_10d-1 HIP-PEL_10d
- GSM7178950 HIP-PEL_10d-2 HIP-PEL_10d
- GSM7178951 HIP-PEL_10d-3 HIP-PEL_10d
- GSM7178952 HIP-SHAM-1 HIP-SHAM
- GSM7178953 HIP-SHAM-2 HIP-SHAM
- GSM7178954 HIP-SHAM-3 HIP-SHAM
- GSM7178955 PEL_3d-1 PEL_3d
- GSM7178956 PEL_3d-2 PEL_3d
- GSM7178957 PEL_3d-3 PEL_3d
- GSM7178958 PEL_3d-GH-1 PEL_3d-GH
- GSM7178959 PEL_3d-GH-2 PEL_3d-GH
- GSM7178960 PEL_3d-GH-3 PEL_3d-GH
- GSM7178961 PEL_10d-1 PEL_10d
- GSM7178962 PEL_10d-2 PEL_10d
- GSM7178963 PEL_10d-3 PEL_10d
- GSM7178964 PEL_10d-GH-1 PEL_10d-GH
- GSM7178965 PEL_10d-GH-2 PEL_10d-GH
- GSM7178966 PEL_10d-GH-3 PEL_10d-GH
- GSM7178967 SHAM-1 SHAM
- GSM7178968 SHAM-2 SHAM
- GSM7178969 SHAM-3 SHAM
- GSM7178970 SHAM-GH-1 SHAM-GH
- GSM7178971 SHAM-GH-2 SHAM-GH
- GSM7178972 SHAM-GH-3 SHAM-GH
- GSE267751 Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption in mice, in part through hippocampal thyroid hormone signaling. 71 samples shares hippocampal, hormone
- GSE328496 Gene expression + ATAC profiling of trisomic hippocampal neurons upon SAHA treatment [RNA-seq] 16 samples shares hippocampal, treatment
- GSE328495 Gene expression + ATAC profiling of trisomic hippocampal neurons upon SAHA treatment [ATAC-seq] 16 samples shares hippocampal, treatment
- GSE277705 Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival. 57 samples shares pel
- GSE288114 Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity [RNA-Seq] 32 samples shares pel
- GSE325339 Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs 24 samples shares pel
- GSE288281 Krüppel-like Factor family members control expression of genes required for serous cavity and alveolar macrophage identities [RNA-seq] 19 samples shares pel
- GSE268137 Multi-organ immunity on a 3D-printed multi-tissue chip with tubing-free impeller pump 18 samples shares pel
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.