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Monocyte membrane-coated nanoparticles (MoNP)-Verteporfin (VP) treatment alleviated the TNFalpha-induced inflammatory response in Endothelial cells

GSE229918 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/10/23 Platform GPL11154
Summary
Atherosclerosis, characterized by the buildup of plaque in arteries, is a major cause of cardiovascular mortality worldwide, as there is no efficient strategy for targeted therapy. However, we have developed a new drug delivery platform called MoNP, which is loaded with VP, a potent inhibitor of YAP/TAZ signaling. To investigate the MoNP-VP treatment effect, EC were pretreated with MoNP or MoNP-VP then induced the inflammation by TNFalpha. After TNFalpha treatment, the cells were collected and extracted the RNA for RNA sequencing (RNA-Seq). The results showed that MoNP-VP significantly decreased the expression of YAP/TAZ-targeted genes and inflammatory markers while upregulating atheroprotective genes. Overall, these findings suggest that MoNP-VP has the potential to serve as an effective drug delivery platform for atherosclerosis.
Published in
Biomimetic nanodrug targets inflammation and suppresses YAP/TAZ to ameliorate atherosclerosis
Huang HC, Wang TY, Rousseau J et al. · Biomaterials 2024 · PMID 38359507 · doi:10.1016/j.biomaterials.2024.122505
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Also filed as BioProject PRJNA951418 and SRA study SRP430502. Searching any of these in the dataset finder brings you back here.

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