GEO series
Distinct transcriptional profile in CD4+ T-lymphocytes among obese children with asthma
GSE230024
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2025/05/01
GPL24676
Summary
Obesity is a risk factor for asthma severity and morbidity, displaying a distinct clinical phenotype that is less responsive to inhaled corticosteroids. CD4+ T-cells are central to the immunologic pathways of asthma and may contribute to the unique obese asthma phenotype. We sought to characterize the single cell CD4+ transcriptional profile among obese children with asthma compared to matched normal weight children with asthma.
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Paper (PMID 39868576) ↗
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