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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons

GSE230520 Homo sapiens (human) Expression microarray 61 samples Submitted 2024/04/15 Platform GPL17930Platform GPL24676
At a glance

Expression microarray · human · 61 samples

What it is
Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
Organism
Homo sapiens (human)
Samples
61 samples: 14 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed expression table (series matrix) and the array files, from NCBI.
Paper
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neuronsCell stem cell · 2024
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons
Al-Dalahmah O, Lam M, McInvale JJ et al. · Cell stem cell 2024 · PMID 38626772 · doi:10.1016/j.stem.2024.03.013
This dataset
Open GSE230520 in finder → Find more human microarray datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230520_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.

Also filed as BioProject PRJNA961691 and SRA study SRP434253. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 38626772) ↗
Study design
14 conditions, mostly with about 4 replicates each
post-mortem brain tissue, FTD ×8 Postmortem human brain, Ctrl , HO ×5 post-mortem brain tissue, Ctrl ×4 iPSC neurons, CtrlSPP1 ×4 iPSC neurons, CtrlGFP ×4 iPSC neurons, FTDshSPP1 ×4 iPSC neurons, FTDsc ×4 Postmortem human brain, FTD, HO ×4 +12 more

Supports a between-group comparison across 55 samples.

How we read this: 14 replicated groups read from 61 sample titles; they account for 55 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 21 more — browse all 61 samples with per-sample file links →

Datasets on a similar topic

Search all human microarray datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.