Anti-epileptic drugs are endocrine disruptors for the human fetal testis ex vivo.
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × DMSO_EH vs 4 × Val_5_EH vs 2 × DMSO_Pool vs 2 × Val_5_PoolGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivoToxicological sciences : an official journal of the Society of Toxicology · 2023
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE230562_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA961768. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7226763 DMSO_EH2817 DMSO_EH
- GSM7226764 DMSO_EH3657 DMSO_EH
- GSM7226765 DMSO_EH2384 DMSO_EH
- GSM7226766 DMSO_EH2710 DMSO_EH
- GSM7226767 DMSO_Pool1 DMSO_Pool
- GSM7226768 DMSO_Pool2 DMSO_Pool
- GSM7226769 Val_5_EH2817 Val_5_EH
- GSM7226770 Val_5_EH3657 Val_5_EH
- GSM7226771 Val_5_EH2384 Val_5_EH
- GSM7226772 Val_5_EH2710 Val_5_EH
- GSM7226773 Val_5_Pool1 Val_5_Pool
- GSM7226774 Val_5_Pool2 Val_5_Pool
- GSE307069 Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in Hidradenitis Suppurativa skin disease 26 samples shares disruptors, endocrine
- GSE252991 Interferon epsilon as a novel anti-viral agent in the testis [human] 48 samples shares testis
- GSE272002 LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC 324 samples shares endocrine
- GSE277212 Insights into intestinal neuroendocrine tumors in relation to normal human EEC differentiation [RNAseq] 27 samples shares endocrine
- GSE254315 Single-cell transcriptome analysis reveals the molecular mechanisms underlying age-related changes in human testis 25 samples shares testis
- GSE281587 NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation 24 samples shares endocrine
- GSE297605 CD8+ T cells in the tumor immune microenvironment modulate resistance to endocrine therapy in hormone receptor-positive breast cancer 174 samples shares endocrine
- GSE261187 Epigenetic priming induces cancer testis antigens and human endogenous retroviruses in glioma for enhanced T cell responses at single cell resolution (bulk RNA-Seq) 20 samples shares testis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.