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DNA accessibility profiling at the single nucleus level of post mortem white matter brain tissue of patients with progressive multiple sclerosis and non-neurological disease controls

GSE231584 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/06/21 Platform GPL24676
Summary
Different lesion types were microdissected out from snap-frozen white matter. Brain nuclei were fluorescence-activated nuclear sorted and treated with Transposase Tn5. Gel beads-in-emulsion was generated, barcoded followed by library construction and sequencing.
Published in
Single-Cell Multi-Omics Map of Cell Type-Specific Mechanistic Drivers of Multiple Sclerosis Lesions
Elkjaer ML, Hartebrodt A, Oubounyt M et al. · Neurology(R) neuroimmunology & neuroinflammation 2024 · PMID 38564686 · doi:10.1212/NXI.0000000000200213
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Also filed as BioProject PRJNA967119 and SRA study SRP436073. Searching any of these in the dataset finder brings you back here.

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