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Dynamic genome Chromatin accessibility of T lymphocyte under microgravity condition

GSE231857 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/05/07 Platform GPL24676
Summary
In space flight,microgravity may be sensed and transmitted through cellular and nuclear structures, thereby altering nuclear plasticity, chromatin organization and openness, which in turn leads to differential gene expression. Studies on genome-wide chromatin openness under microgravity environments will help to clarify whether the Earth's gravity is stable and maintains the structure and openness of chromatin, as well as the steady-state conditions that constitute genome modification. At the same time, it will provide a strong scientific basis for astronaut's protection under extreme conditions.
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Direct links to NCBI, no account and no request form: the whole study as GSE231857_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA968162 and SRA study SRP436327. Searching any of these in the dataset finder brings you back here.

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