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The phosphorylation of FOXA1-S331 is indispensable for FOXA1-AR dependent cistrome [RNA-seq]

GSE232124 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/01 Platform GPL16791
Summary
To define the function of FOXA1-S331 phosphorylation, we substituted S331 in both FOXA1 alleles for alanine in C4-2 cells via CRISPR/Cas9-based gene editing, thereby generating phosphorylation incompetent FOXA1S331A cells. We directly assessed the consequences of phospho-incompetent FOXA1S331A mutation on the transcription profile, chromatin deposition of FOXA1, AR, H3K27ac and chromatin accessibility.
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Also filed as BioProject PRJNA971091 and SRA study SRP436797. Searching any of these in the dataset finder brings you back here.

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