CD49a expression and induction of cytotoxicity on human tissue-resident CD8+ T cells is controlled by RUNX2 and RUNX3 transcription factor activity
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 55 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 55 samples: 40 distinct titles, 9 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232239_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA971328. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 55 sample titles: 40 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7324227 CM Day1 replicate 1
- GSM7324228 CD103- CD49a- Day 14 replicate 1
- GSM7324229 CD103+ CD49a- Day 14 replicate 1
- GSM7324230 CD103+ CD49a+ Day 14 replicate 1
- GSM7324231 CD103-cCD49a+ Day 14 replicate 1
- GSM7324232 CM Day 1 replicate 2
- GSM7324233 CD103- CD49a- Day 14 replicate 2
- GSM7324234 CD103+ CD49a- Day 14 replicate 2
- GSM7324235 CD103+ CDD49a+ Day 14 replicate 2
- GSM7324236 CD103- CD49a+ Day 14 replicate 2
- GSM7324237 CM Day 1 replicate 3
- GSM7324238 CD103- CD49a- Day 14 replicate 3
- GSM7324239 CD103+ CD49a- Day 14 replicate 3
- GSM7324240 CD103+ CD49a+ Day 14 replicate 3
- GSM7324241 CD103- CD49a+ Day 14 replicate 3
- GSM7324242 CD8 T cells, Ctrl, Donor 1_E93
- GSM7324243 CD8 T cells, Ctrl, Donor 2_E93
- GSM7324244 CD8 T cells, Ctrl, Donor 3_E95
- GSM7324245 CD8 T cells, Ctrl, Donor 4_E95
- GSM7324246 CD8 T cells, Ctrl, Donor 5_E95
- GSM7324247 CD8 T cells, Runx2_AB, Donor 1_E93
- GSM7324248 CD8 T cells, Runx2_AB, Donor 2_E93
- GSM7324249 CD8 T cells, Runx2_AB, Donor 3_E95
- GSM7324250 CD8 T cells, Runx2_AB, Donor 4_E95
- GSM7324251 CD8 T cells, Runx2_AB, Donor 5_E95
- GSM7324252 CD8 T cells, Runx2_AC, Donor 1_E93
- GSM7324253 CD8 T cells, Runx2_AC, Donor 2_E93
- GSM7324254 CD8 T cells, Runx2_AC, Donor 3_E95
- GSM7324255 CD8 T cells, Runx2_AC, Donor 4_E95
- GSM7324256 CD8 T cells, Runx2_AC, Donor 5_E95
- GSM7324257 CD8 T cells, Runx3_AD, Donor 1_E93
- GSM7324258 CD8 T cells, Runx3_AD, Donor 2_E93
- GSM7324259 CD8 T cells, Runx3_AD, Donor 3_E95
- GSM7324260 CD8 T cells, Runx3_AD, Donor 4_E95
- GSM7324261 CD8 T cells, Runx3_AD, Donor 5_E95
- GSM7324262 CD8 T cells, Runx3_AE, Donor 1_E93
- GSM7324263 CD8 T cells, Runx3_AE, Donor 2_E93
- GSM7324264 CD8 T cells, Runx3_AE, Donor 4_E95
- GSM7324265 CD8 T cells, Runx3_AE, Donor 5_E95
- GSM7324278 Dermis CD103-, donor 2017#C23
+ 15 more — browse all 55 samples with per-sample file links →
- GSE310729 Age-independent and targetable transcription factor networks regulate CD8+ T cell senescence in aging humans 83 samples shares cd8, transcription
- GSE247647 Cell state and transcription factor modulation during extended CD8+ T-cell expansion ex vivo 51 samples shares cd8, transcription
- GSE289496 Granzyme K CD8⁺ T cells with tissue-resident features promote intestinal inflammation in patients with Crohn’s disease 45 samples shares cd8, tissue-resident
- GSE317789 Single-cell and spatial profiling reveal cDC2A-CXCL13+ CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus 42 samples shares cd8, cytotoxicity
- GSE245739 The transcription factor IRF4 impedes human CD8 T-cell function and promotes cells proliferation and PD-1 expression 40 samples shares cd8, transcription
- GSE284015 GZMK-expressing tissue-resident memory CD8+ T cells mediate human intestinal acute graft-versus-host disease 26 samples shares cd8, tissue-resident
- GSE299807 Similar activation-driven transcriptional programs in lung CMV- and flu- specific memory CD8+ T cells despite differences in tissue residency profiles 25 samples shares cd8, transcription
- GSE310384 Age-independent and targetable transcription factor networks regulate CD8+ T cell senescence in aging humans 24 samples shares cd8, transcription
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.