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Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development [human ATAC-seq]

GSE232478 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/06/21 Platform GPL28038Platform GPL24676
Summary
Mammalian kidneys maintain fluid homeostasis through the cellular activity of nephrons and the conjoined collecting system. Each epithelial network originates from distinct progenitor cell populations that reciprocally interact during development. To extend our understanding of human and mouse kidney development, we profiled chromatin organization (ATAC-seq) and gene expression (RNA-seq) in developing human and mouse kidneys. Data were analyzed at a species level and then integrated into a common, cross-species multimodal data set. Comparative analysis of cell types and developmental trajectories identified conserved and divergent features of chromatin organization and linked gene activity, revealing species- and cell-type specific regulatory programs. Identification of human-specific enhancer regions linked through GWAS studies to kidney disease highlights the potential of developmental modeling to provide clinical insight.
Published in
Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processes
Parvez RK, Kim DK, Csipán RL et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 40354537 · doi:10.1073/pnas.2418471122
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Also filed as BioProject PRJNA972293 and SRA study SRP563470. Searching any of these in the dataset finder brings you back here.

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