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Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development

GSE232482 Homo sapiens (human) Single-cell RNA-seq 36 samples Submitted 2024/06/20 Platform GPL28457Platform GPL24676Platform GPL28038Platform GPL20301Platform GPL21103
At a glance

Single-cell RNA-seq · human · 36 samples

What it is
Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
Organism
Homo sapiens (human)
Samples
36 samples: 5 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processesProceedings of the National Academy of Sciences of the United States of America · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Dmrt2 and Hmx2 direct intercalated cell diversity in the mammalian kidney through antagonistic and supporting regulatory processes
Parvez RK, Kim DK, Csipán RL et al. · Proceedings of the National Academy of Sciences of the United States of America 2025 · PMID 40354537 · doi:10.1073/pnas.2418471122
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232482_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.

Also filed as BioProject PRJNA972292 and SRA study SRP437542. Searching any of these in the dataset finder brings you back here.

Study design
5 conditions, mostly in duplicate
P0 mouse, scRNA-seq, rep M ×7 P0 mouse, scRNA-seq, rep F ×6 15.6 Wk human fetal, snRNA-seq, rep F ×2 P0 mouse, snATAC-seq, rep F ×2 P0 mouse, snATAC-seq, rep M ×2 10.6 Wk human fetal, snATAC-seq, rep M ×1 11.1 Wk human fetal, snATAC-seq, rep M ×1 11.6 Wk human fetal, snATAC-seq, rep M ×1 +14 more

Supports a between-group comparison across 19 samples.

How we read this: 5 replicated groups read from 36 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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