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FOXA2/AP-1 drives prostate cancer lineage plasticity

GSE232555 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 101 samples Submitted 2024/04/22 Platform GPL18573Platform GPL30172Platform GPL30173
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 101 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Topic
Prostate cancerThis series is part of our curated briefing on it.
Samples
101 samples: 25 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancerNature communications · 2024
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer
Wang Z, Townley SL, Zhang S et al. · Nature communications 2024 · PMID 38851846 · doi:10.1038/s41467-024-49234-9
This dataset
Open GSE232555 in finder → Find more RNA-seq datasets → Prostate cancer landscape →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232555_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA972713 and SRA study SRP437782. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 38851846) ↗
Study design
25 conditions, mostly in triplicate
PDX201.1, vehicle, ChIP-FOXA1, repeat ×4 PDX201.2, vehicle, ChIP-FOXA2, repeat ×4 PDX201.1, vehicle, ChIP-H3K27Ac, repeat ×3 LNCaP_CTL_cells,vehicle, repeat ×3 LNCaP_FOXA2OE, vehicle, repeat ×3 LNCaP_CTL_cells, DHT 10nM repeat ×3 LNCaP_FOXA2OE_cells, DHT 10nM repeat ×3 NCI-H660 cells, siFOXA2, repeat ×3 +45 more

Supports a between-group comparison across 73 samples.

How we read this: 25 replicated groups read from 101 sample titles; they account for 73 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 61 more — browse all 101 samples with per-sample file links →

More Prostate cancer datasets

Search all RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.