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H3K27me3 and H3K4me3 ChIP-seq on DMSO or MAK683 treated cancer cell

GSE232613 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/04/04 Platform GPL24676
Summary
The methyltransferase Polycomb Repressive Complex 2 (PRC2), composed of EZH2, SUZ12, and EED subunits, is associated with transcriptional repression via tri-methylation of histone H3 on lysine 27 residue (H3K27me3). PRC2 is a validated drug target, as the EZH2 gain-of-function mutations identified in patient samples drive tumorigenesis. PRC2 inhibitors have been discovered and demonstrated anti-cancer efficacy in clinic. However, their pharmacological mechanisms are poorly understood. MAK683 is a potent EED inhibitor in clinical development. The overall goal of our study is to understand the molecular events leading to tumor regression after PRC2 inhibition. Our study revealed that BMP-ACVR1 signaling pathway as a critical component for the anti-lymphoma efficacy of PRC2 inhibitor.
Published in
BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma
Liu D, Li Z, Tan D et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 · PMID 38229201 · doi:10.1002/advs.202306499
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Also filed as BioProject PRJNA973025 and SRA study SRP437979. Searching any of these in the dataset finder brings you back here.

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