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RAVER1 interconnects TGFB signaling, EMT and miR/RISC activity by modulating alternative splicing [A549_RAVER1_KO]

GSE232716 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/17 Platform GPL30882
Summary
The depletion and deletion of RAVER1 substantially impairs the 2D-proliferation of tumor cells, vitality in 3D cell models and the growth of subcutaneous xenografts in nude mice. Disturbance of RAVER1 affects various cancer hallmark pathways manifesting in deregulated E2F/DREAM-controlled transcription and broadly hampered microRNA-dependent gene silencing. In carcinoma-derived cell models, impaired control by microRNAs (miR) leads to the upregulation of various tumor suppressors like BTG2, which is suppressed by the most abundant oncomiR 21-5p.
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Also filed as BioProject PRJNA973630 and SRA study SRP438227. Searching any of these in the dataset finder brings you back here.

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