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OTUB2 silencing promotes ovarian cancer via mitochondrial metabolic reprogramming and can be synthetically targeted by CA9 inhibition

GSE232772 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/04/19 Platform GPL24676
Summary
These findings delineate the mechanism of OTUB2 epigenetic silencing in ovarian cancer, demonstrate the critical roles of OTUB2/SNX29P2 in inhibiting glycolysis and eliciting cuproptosis in cancer cells and suggest that CA9 inhibitor treatment is a promising therapeutic option for OTUB2-silenced tumors. To investigate the downstream pathway regulated by OTUB2/SNX29P2, we performed RNA sequencing (RNA-seq) in ES-2 cells expressing EV, OTUB2 or SNX29P2.
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Also filed as BioProject PRJNA973945 and SRA study SRP438424. Searching any of these in the dataset finder brings you back here.

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