Muscle-specific rescue of Bmal1 impacts survival and health span of the Bmal1-KO mouse
RNA-seq (gene expression) · mouse · 72 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 72 samples: 16 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Targeted Bmal1 restoration in muscle prolongs lifespan with systemic health effects in aging modelJCI insight · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE232957_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA974479 and SRA study SRP438697. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 72 samples.
How we read this: 16 replicated groups read from 72 sample titles; they account for 72 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7398508 WT_GTN_10w_rep2 WT_GTN_10w
- GSM7398509 WT_GTN_10w_rep3 WT_GTN_10w
- GSM7398510 WT_GTN_10w_rep4 WT_GTN_10w
- GSM7398511 WT_GTN_10w_rep5 WT_GTN_10w
- GSM7398512 WT_GTN_10w_rep6 WT_GTN_10w
- GSM7398513 WT_GTN_10w_rep7 WT_GTN_10w
- GSM7398514 KO_GTN_10w_rep1 KO_GTN_10w
- GSM7398515 KO_GTN_10w_rep2 KO_GTN_10w
- GSM7398516 KO_GTN_10w_rep3 KO_GTN_10w
- GSM7398517 KO_GTN_10w_rep5 KO_GTN_10w
- GSM7398518 KO_GTN_10w_rep6 KO_GTN_10w
- GSM7398519 KO_GTN_10w_rep7 KO_GTN_10w
- GSM7398520 AAV_GTN_10w_rep1 AAV_GTN_10w
- GSM7398521 AAV_GTN_10w_rep2 AAV_GTN_10w
- GSM7398522 AAV_GTN_10w_rep3 AAV_GTN_10w
- GSM7398523 AAV_GTN_10w_rep4 AAV_GTN_10w
- GSM7398524 AAV_GTN_10w_rep5 AAV_GTN_10w
- GSM7398525 AAV_GTN_10w_rep6 AAV_GTN_10w
- GSM7398526 AAV_GTN_10w_rep7 AAV_GTN_10w
- GSM7398527 WT_GTN_40w_rep1 WT_GTN_40w
- GSM7398528 WT_GTN_40w_rep2 WT_GTN_40w
- GSM7398529 WT_GTN_40w_rep3 WT_GTN_40w
- GSM7398530 WT_GTN_40w_rep4 WT_GTN_40w
- GSM7398531 WT_GTN_40w_rep5 WT_GTN_40w
- GSM7398532 KO_GTN_40w_rep1 KO_GTN_40w
- GSM7398533 KO_GTN_40w_rep2 KO_GTN_40w
- GSM7398534 KO_GTN_40w_rep3 KO_GTN_40w
- GSM7398535 KO_GTN_40w_rep4 KO_GTN_40w
- GSM7398536 KO_GTN_40w_rep5 KO_GTN_40w
- GSM7398537 AAV_GTN_40w_rep1 AAV_GTN_40w
- GSM7398538 AAV_GTN_40w_rep2 AAV_GTN_40w
- GSM7398539 AAV_GTN_40w_rep3 AAV_GTN_40w
- GSM7398540 AAV_GTN_40w_rep4 AAV_GTN_40w
- GSM7398541 AAV_GTN_40w_rep5 AAV_GTN_40w
- GSM7398542 KO_LIV_40w_rep1 KO_LIV_40w
- GSM7398543 KO_LIV_40w_rep2 KO_LIV_40w
- GSM7398544 KO_LIV_40w_rep3 KO_LIV_40w
- GSM7398545 KO_LIV_40w_rep4 KO_LIV_40w
- GSM7398546 AAV_LIV_40w_rep1 AAV_LIV_40w
- GSM7398547 AAV_LIV_40w_rep2 AAV_LIV_40w
+ 32 more — browse all 72 samples with per-sample file links →
- GSE297376 A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration [Bmal1-KO] 25 samples shares bmal1-ko, bmal1
- GSE282175 RNA-seq of retinal microglia and non-microglial retina cells in WT (Bmal1f/f) and microglial Bmal1-KO (Bmal1-mg/-mg) mice 18 samples shares bmal1-ko, bmal1
- GSE277705 Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival. 57 samples shares survival, span
- GSE262714 The Core Circadian Clock Factor, Bmal1, Transduces Sex-specific Differences in Both Rhythmic and Nonrhythmic Gene Expression in the Mouse Heart 96 samples shares bmal1
- GSE296764 Transcriptional expression of SCN, liver and heart at CT0 and CT12 after central VIP knockout of Bmal1 76 samples shares bmal1
- GSE253735 Loss of skeletal muscle Bmal1 +/- Exercise Training [Mouse liver, heart, inguinal white adipose and lung tissues 64 samples shares bmal1
- GSE282908 Control of Circadian Glucose Metabolism through BMAL1-HIF Axis in Obesity 51 samples shares bmal1
- GSE294336 BMAL1 and YAP cooperate to hijack enhancers and promote inflammation in the aged epidermis [RNA-seq Aged_adult] 48 samples shares bmal1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.