STAT3 inhibition permits epigenetic reprogramming and TLR9/IRF8-driven differentiation of inv(16) acute myeloid leukemia.
DNA methylation · mouse · 41 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 41 samples: 9 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE233099_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA974904 and SRA study SRP438873. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 41 samples.
How we read this: 9 replicated groups read from 41 sample titles; they account for 41 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7401358 PBS rep1 PBS
- GSM7401359 PBS rep2 PBS
- GSM7401360 PBS rep3 PBS
- GSM7401361 CpG1668_rep1 CpG1668
- GSM7401362 CpG1668_rep2 CpG1668
- GSM7401363 CpG1668_rep3 CpG1668
- GSM7401364 Combination_rep1 Combination
- GSM7401365 Combination_rep2 Combination
- GSM7401366 Combination_rep3 Combination
- GSM7401367 doxycycline_rep1 doxycycline
- GSM7401368 doxycycline_rep2 doxycycline
- GSM7401369 doxycycline_rep3 doxycycline
- GSM7401370 PBS_rep1 PBS
- GSM7401371 PBS_rep2 PBS
- GSM7401372 PBS_rep3 PBS
- GSM7401373 PBS_rep4 PBS
- GSM7401374 SCR_rep1 SCR
- GSM7401375 SCR_rep2 SCR
- GSM7401376 SCR_rep3 SCR
- GSM7401377 SCR_rep4 SCR
- GSM7401378 DEC_rep1 DEC
- GSM7401379 DEC_rep2 DEC
- GSM7401380 DEC_rep3 DEC
- GSM7401381 DEC_rep4 DEC
- GSM7401382 PBS_1 PBS
- GSM7401383 PBS_2 PBS
- GSM7401384 PBS_3 PBS
- GSM7401385 PBS_4 PBS
- GSM7401386 CD11b_1 CD11b
- GSM7401387 CD11b_2 CD11b
- GSM7401388 CD11b_3 CD11b
- GSM7401389 CD11b_4 CD11b
- GSM7401390 CD11bplus_1 CD11bplus
- GSM7401391 CD11bplus_2 CD11bplus
- GSM7401392 CD11bplus_3 CD11bplus
- GSM7401393 CD11bplus_4 CD11bplus
- GSM7401394 PBS PBS
- GSM7401395 Decoy2 Decoy
- GSM7401396 Decoy3 Decoy
- GSM7401397 Decoy5 Decoy
+ 1 more — browse all 41 samples with per-sample file links →
- GSE294258 Intracellular iron homeostasis-regulated epigenetic reprogramming contributes to -7/del(7q) leukemia 71 samples shares reprogramming, epigenetic, leukemia
- GSE282695 STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response 18 samples shares stat3, reprogramming
- GSE222745 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [scRNA-Seq] 422 samples shares reprogramming, epigenetic
- GSE286574 Intrauterine hyperglycemia impairs primordial germ cell development and fertility by sex-specific epigenetic reprogramming interference in mice offspring [ATAC-seq] 30 samples shares reprogramming, epigenetic
- GSE270509 In vivo CRISPR screen reveals interplay of epigenetic regulators underlies kinetics of hepatobiliary reprogramming [RNA-Seq] 27 samples shares reprogramming, epigenetic
- GSE335147 Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response 24 samples shares reprogramming, inhibition
- GSE319246 ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer’s Disease via Epigenetic Reprogramming of the AsxL1/LXRα–H3K4me3 Axis 24 samples shares reprogramming, epigenetic
- GSE99296 α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming 18 samples shares reprogramming, epigenetic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.