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The single-cell level molecular characteristics according to combination immunotherapy response of non-small cell lung cancer patients.

GSE233203 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2025/08/27 Platform GPL20795
Summary
Non-small cell lung cancer patients finally acquire EGFR-TKI resistance. For these patients, combination immunotherapy, atezolizumab plus bevacizumab and carboplatin/paclitaxel (ABCP), was proposed as a therapy based on targetting both cancer and stromal cells. Despite of relatively good therapeutic outcome, precise mechanism was not fully understood. To dissect tumor microenvironment and regulatory mechanism involved in ABCP response, we performed scRNA-seq analysis from patients to receive ABCP.
Published in
VEGF Signal Complexity Confers Resistance to Atezolizumab, Bevacizumab, Carboplatin, and Paclitaxel in EGFR-Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
Hong S, Yu N, Cho JY et al. · MedComm 2025 · PMID 40843133 · doi:10.1002/mco2.70335
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Direct links to NCBI, no account and no request form: the whole study as GSE233203_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA975448 and SRA study SRP439124. Searching any of these in the dataset finder brings you back here.

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