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The BET inhibitor GNE-987 effectively induces anti-cancer effects byfocusing on super-enhancers inT-cell acute lymphoblastic leukemia [Cut & Tag]

GSE233299 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/05/17 Platform GPL11154
Summary
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignant tumor that arises from T progenitor cells and accounts for 15% of childhood ALL and 25% of adult ALL cases. GNE-987 is a new chimeric molecule designed by proteolysis-targeting chimeras (PROTAC) technology. that combines an effective bromodomains and extra-targeting (BET) protein inhibitor with E3 ubiquitin ligase VHL(Von Hippel Lindau) and effectively induces proteasomal degradation of bromodomain-containing protein 4 (BRD4). GNE-987 and persistently inhibits cell proliferation and induces apoptosis, however, its anti-tumor activity GNE-987 in T-ALL has not been clarified, Here, we explore the molecular mechanisms underlying GNE-987's anti-tumor effect in T-ALL using RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP seq) and Cut&Tag technology.
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Direct links to NCBI, no account and no request form: the whole study as GSE233299_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA975832 and SRA study SRP439298. Searching any of these in the dataset finder brings you back here.

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