GEO series
Exploring DNMT1 genome binding under homeostatic and hypomethylating conditions [ChIP-seq]
GSE233726
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2026/05/17
GPL24676
Summary
Genome wide binding analysis of endogenous DNMT1 has yet to be succefully determined, owing to the difficulty of preserving DNA interactions during sonication. Using a light sonication protocol, we successfully ChIP DNMT1 and reveal its intrinsicDNA binding preferences genome wide under homeostatic and hypomethylating conditions. We discover that DNMT1 binds to accessible unmethylated CpG islands during homeostasis, then redistributes to hemi-methylated inaccessible DNA under hypomethylating conditions. Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for H3K27me3 and endogenous DNMT1 in MV4-11 cells.
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