Lung injury shifts pulmonary capillary endothelial cells towards regeneration-associated Lrg1+ subpopulations with delayed dynamics in aged mice
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male miceNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234199_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA980271 and SRA study SRP441200. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7454030 Young D14, scRNAseq
- GSM7454031 Young D14, HTO
- GSM7454032 Old D14, scRNAseq
- GSM7454033 Old D14, HTO
- GSM7454034 Young D28, scRNAseq
- GSM7454035 Young D28, HTO
- GSM7454036 Old D28, scRNAseq
- GSM7454037 Old D28, HTO
- GSM7454038 Young D60, scRNAseq
- GSM7454039 Young D60, HTO
- GSM7454040 Old D60, scRNAseq
- GSM7454041 Old D60, HTO
- GSM7454042 YoungD14 , Spatial Transcriptomics
- GSM7454043 YoungD14bis , Spatial Transcriptomics
- GSM7454044 OldD14a , Spatial Transcriptomics
- GSM7454045 OldD14b , Spatial Transcriptomics
- GSM7454046 YoungD28 , Spatial Transcriptomics
- GSM7454047 YoungD28bis , Spatial Transcriptomics
- GSM7454048 OldD28a , Spatial Transcriptomics
- GSM7454049 OldD28b , Spatial Transcriptomics
- GSE229427 Tracking spatio-temporal dynamics of the endothelial niche during fetal hematopoiesis 216 samples shares endothelial, dynamics
- GSE271971 Pulmonary microvascular endothelial cells support alveolar epithelial growth via bone morphogenetic protein 6 secretion 72 samples shares endothelial, pulmonary
- GSE316502 Transcriptomic Profiling of the Sex-linked Biological Pathways of Severe Pulmonary Arterial Hypertension associated with Endothelial Cell Caveolin-1 Depletion and Chronic Hypoxia 35 samples shares endothelial, pulmonary
- GSE314943 Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis 18 samples shares endothelial, pulmonary
- GSE253438 A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice 48 samples shares endothelial
- GSE281268 A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes [scRNA-seq] 28 samples shares endothelial
- GSE192687 Single-cell RNAseq analysis of renal endothelial cells in murine diabetic nephropathy 5464 samples shares endothelial
- GSE205411 Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations 2219 samples shares subpopulations
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.