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NF-κB-induced expression of T-bet suppresses proliferation of malignant B cells and is associated with good prognosis in chronic lymphocytic leukemia [scATAC-seq]

GSE234224 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/06/01 Platform GPL24247
Summary
The T-box transcription factor T-bet is encoded by Tbx21 and was identified to play a role in aging and tissue localization of B cells. T-bet expression was detected in malignant B cells but its potential role in B-cell malignancies remains largely unexplored. We used single cell RNA sequencing (scRNA-seq) and the assay for transposase accessible chromatin using sequencing (scATAC-seq) to analyze the regulatory role of T-bet in TCL1 leukemia.
Published in
T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia
Roessner PM, Seufert I, Chapaprieta V et al. · Blood 2024 · PMID 38684038 · doi:10.1182/blood.2023021990
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Also filed as BioProject PRJNA980577 and SRA study SRP441324. Searching any of these in the dataset finder brings you back here.

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