Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target [RNA-Seq]
RNA-seq (gene expression) · mouse · 79 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 79 samples: 19 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A dataset profiling the multiomic landscape of the prefrontal cortex in amyotrophic lateral sclerosisGigaScience · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234245_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA980618 and SRA study SRP441344. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 73 samples.
How we read this: 19 replicated groups read from 79 sample titles; they account for 73 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7458093 FUS,mut,female,S574 FUS,mut,female,S
- GSM7458094 FUS,mut,female,S575 FUS,mut,female,S
- GSM7458095 FUS,mut,female,S581 FUS,mut,female,S
- GSM7458096 FUS,mut,female,S785 FUS,mut,female,S
- GSM7458097 FUS,mut,female,S782 FUS,mut,female,S
- GSM7458098 FUS,mut,male,S784 FUS,mut,male,S
- GSM7458099 FUS,mut,male,S858 FUS,mut,male,S
- GSM7458100 FUS,mut,male,S567 FUS,mut,male,S
- GSM7458101 FUS,mut,male,S578 FUS,mut,male,S
- GSM7458102 FUS,mut,male,S881 FUS,mut,male,S
- GSM7458103 FUS,ctrl,male,S572 FUS,ctrl,male,S
- GSM7458104 FUS,ctrl,female,S565 FUS,ctrl,female,S
- GSM7458105 FUS,ctrl,female,S571 FUS,ctrl,female,S
- GSM7458106 FUS,ctrl,female,S850 FUS,ctrl,female,S
- GSM7458107 FUS,ctrl,female,S875 FUS,ctrl,female,S
- GSM7458108 FUS,ctrl,female,S876 FUS,ctrl,female,S
- GSM7458109 FUS,ctrl,male,S776 FUS,ctrl,male,S
- GSM7458110 FUS,ctrl,male,S780 FUS,ctrl,male,S
- GSM7458111 FUS,ctrl,male,S586 FUS,ctrl,male,S
- GSM7458112 TDP43,ctrl,male,S0841 TDP43,ctrl,male,S
- GSM7458113 TDP43,ctrl,male,S0842 TDP43,ctrl,male,S
- GSM7458114 TDP43,ctrl,male,S0843 TDP43,ctrl,male,S
- GSM7458115 TDP43,ctrl,male,S0844 TDP43,ctrl,male,S
- GSM7458116 TDP43,ctrl,male,S0845 TDP43,ctrl,male,S
- GSM7458117 TDP43,ctrl,female,S0846 TDP43,ctrl,female,S
- GSM7458118 TDP43,ctrl,female,S0847 TDP43,ctrl,female,S
- GSM7458119 TDP43,ctrl,female,S0848 TDP43,ctrl,female,S
- GSM7458120 TDP43,ctrl,female,S0849 TDP43,ctrl,female,S
- GSM7458121 TDP43,ctrl,female,S0850 TDP43,ctrl,female,S
- GSM7458122 TDP43,mut,female,S1812 TDP43,mut,female,S
- GSM7458123 TDP43,mut,male,S1814 TDP43,mut,male,S
- GSM7458124 TDP43,mut,male,S1815 TDP43,mut,male,S
- GSM7458125 TDP43,mut,male,S1816 TDP43,mut,male,S
- GSM7458126 TDP43,mut,female,S1821 TDP43,mut,female,S
- GSM7458127 TDP43,mut,male,S1827 TDP43,mut,male,S
- GSM7458128 TDP43,mut,female,S1835 TDP43,mut,female,S
- GSM7458129 TDP43,mut,female,S1840 TDP43,mut,female,S
- GSM7458130 TDP43,mut,female,S1843 TDP43,mut,female,S
- GSM7458131 TDP43,mut,male,S1845 TDP43,mut,male,S
- GSM7458132 SOD1,ctrl,female,S8950 SOD1,ctrl,female,S
+ 39 more — browse all 79 samples with per-sample file links →
- GSE234246 Multiomic Profile Integration Reveals Early Signatures of Amyotrophic Lateral Sclerosis and Suggests the MAPK Pathway as a Therapeutic Target 158 samples shares mapk, integration, amyotrophic, therapeutic, signatures, multiomic, sclerosis, suggests
- GSE307773 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [RNA-Seq] 175 samples shares mapk, therapeutic
- GSE307774 Oncogenic MAPK signalling induces epithelial cell state change and therapeutic resistance in vivo [scRNA-Seq] 29 samples shares mapk, therapeutic
- GSE223323 Enterocyte like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability 148 samples shares therapeutic, signatures
- GSE301751 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 7/9) 53 samples shares therapeutic, signatures
- GSE310507 Therapeutic Efficacy, Biomarker Signatures and Translatability of Semaglutide in the Liver Biopsy-Confirmed GAN DIO-MASH Mouse Model (study 6) 24 samples shares therapeutic, signatures
- GSE255321 Therapeutic effects of FGF21 mimetic bFKB1 on MASH and atherosclerosis in Ldlr-/-.Leiden mice 24 samples shares therapeutic, sclerosis
- GSE333191 Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model 16 samples shares integration, signatures
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.