The effect of METTL3 RNA methyltransferase inhibition on breast cancer cell gene expression
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Breast cancerThis series is part of our curated briefing on it.
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Functional and clinical significance of the RNA m(6)A methyltransferase complex in breast cancerNPJ breast cancer · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE234322_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA980832 and SRA study SRP441398. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7464989 MCF-7 Vehicle 1 MCF-7 Vehicle
- GSM7464990 MCF-7 Vehicle 2 MCF-7 Vehicle
- GSM7464991 MCF-7 Vehicle 3 MCF-7 Vehicle
- GSM7464992 MCF-7 Estradiol 1 MCF-7 Estradiol
- GSM7464993 MCF-7 Estradiol 2 MCF-7 Estradiol
- GSM7464994 MCF-7 Estradiol 3 MCF-7 Estradiol
- GSM7464995 MCF-7 STM2457 1 MCF-7 STM2457
- GSM7464996 MCF-7 STM2457 2 MCF-7 STM2457
- GSM7464997 MCF-7 STM2457 3 MCF-7 STM2457
- GSM7464998 MCF-7 Estradiol + STM2457 1 MCF-7 Estradiol + STM24…
- GSM7464999 MCF-7 Estradiol + STM2457 2 MCF-7 Estradiol + STM24…
- GSM7465000 MCF-7 Estradiol + STM2457 3 MCF-7 Estradiol + STM24…
- GSM7465001 MDA-MB-231 Vehicle 1 MDA-MB-231 Vehicle
- GSM7465002 MDA-MB-231 Vehicle 2 MDA-MB-231 Vehicle
- GSM7465003 MDA-MB-231 Vehicle 3 MDA-MB-231 Vehicle
- GSM7465004 MDA-MB-231 STM2457 1 MDA-MB-231 STM2457
- GSM7465005 MDA-MB-231 STM2457 2 MDA-MB-231 STM2457
- GSM7465006 MDA-MB-231 STM2457 3 MDA-MB-231 STM2457
- GSE104193 Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signalling and malignant features in vitro and in vivo 32 samples same disease briefing · shares breast
- GSE104675 Role for the Transcriptional Activator ZRF1 in Breast Cancer Progression and Endocrine Resistance 6 samples same disease briefing · shares breast
- GSE10886 A Supervised Risk Predictor of Breast Cancer Based on Biological Subtypes 226 samples same disease briefing · shares breast
- GSE11121 The humoral immune system has a key prognostic impact in node-negative breast cancer 200 samples same disease briefing · shares breast
- GSE10885 An integromic analysis reveals that metaplastic carcinomas are distinct from basal-like tumors. 244 samples same disease briefing
- GSE313114 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-Seq dose_response] 21 samples shares mettl3, inhibition
- GSE231526 DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer 18 samples shares inhibition, breast
- GSE342455 Transcriptomic profiling of tumor-associated macrophages following pharmacological SYK inhibition in a human breast cancer co-culture model 6 samples shares inhibition, breast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.