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Comprehensive analysis of mesenchymal cells reveals a deregulated TGF-B/Wnt/HOXB7 axis in patients with myelofibrosis [ATAC-seq]

GSE234389 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2024/12/18 Platform GPL18573
Summary
In this study, through a patient-sample driven transcriptomic and epigenetic description of the MF microenvironment landscape and cell-based analyses, we identify HOXB7 overexpression and more precisely a novel TGF-B-Wnt-HOXB7 pathway as associated to a pro-fibrotic and pro-osteoblastic biased differentiation of mesenchymal stromal cells (MSCs).
Published in
Comprehensive analysis of mesenchymal cells reveals a dysregulated TGF-β/WNT/HOXB7 axis in patients with myelofibrosis
Ganesan S, Awan-Toor S, Guidez F et al. · JCI insight 2024 · PMID 39470742 · doi:10.1172/jci.insight.173665
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Also filed as BioProject PRJNA981175. Searching any of these in the dataset finder brings you back here.

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