GEO series
DDX6 reshapes the cancer RNA editome to suppress RNA-induced innate immunity [Bulk RNA-seq]
GSE234652
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2026/06/01
GPL20301
Summary
ADAR1 is thought to be an immune suppressor and maintains self-tolerance to endogenous nucleic acids through its A-to-I RNA editing catalytic activity. Its editing activity is tightly regulated by an array of different proteins and factors. In this study, we investigated the role of DDX6 in A-to-I RNA editing regulation and how this in turns regulate dsRNA-induced immunity.
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