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ZDHHC15 mediates Hippo/YAP pathway palmitoylation and regulates tumor progression [TOV-112D]

GSE235254 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/17 Platform GPL24676
Summary
The Post-translational modification of Hippo/YAP pathway members plays an important role in regulating the activation of Hippo/YAP pathway and its effects in tumors. S-Palmitoylation, also known as S-acylation,is the most common protein Lipid modification, mainly composed of palmitoyl transferases (PATs) from the DHHC (Asp His His Cys) family Catalysis. The results showed that ZDHHC15 mediated palmitoylation of KIBRA up-regulated the expression of YAP downstream target genes, and regulated the invasion function of breast cancer and ovarian cancer cells. The research results will reveal new regulatory mechanisms of the Hippo pathway
Published in
Dietary Palmitic Acid Drives a Palmitoyltransferase ZDHHC15-YAP Feedback Loop Promoting Tumor Metastasis
Wang J, Shen D, Jiang J et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 39686664 · doi:10.1002/advs.202409883
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Also filed as BioProject PRJNA985621 and SRA study SRP445022. Searching any of these in the dataset finder brings you back here.

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