Rescuing early Parkinson-induced hyposmia prevents dopaminergic system failure [human]
Single-cell RNA-seq · human · 24 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 16 × C vs 5 × PDGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism modelseLife · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE235330_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA985706 and SRA study SRP445041. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 21 samples.
How we read this: 2 replicated groups read from 24 sample titles; they account for 21 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7500563 C8 C
- GSM7500564 control_TST
- GSM7500565 C4 C
- GSM7500566 C6 C
- GSM7500567 C3 C
- GSM7500568 C11 C
- GSM7500569 control_Soma
- GSM7500570 C2 C
- GSM7500571 C7 C
- GSM7500572 C9 C
- GSM7500573 control_Habib
- GSM7500574 C10 C
- GSM7500575 C1 C
- GSM7500576 C5 C
- GSM7500577 C23 C
- GSM7500578 C45 C
- GSM7500579 C72 C
- GSM7500580 C73 C
- GSM7500581 C87 C
- GSM7500582 PD106 PD
- GSM7500583 PD188 PD
- GSM7500584 PD194 PD
- GSM7500585 PD348 PD
- GSM7500586 PD423 PD
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.