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Impact of Palbociclib (PD-0332991; CDK4/6 inhibitor) on gene expression of MCF7 cells

GSE235350 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/17 Platform GPL18573
Summary
Studying DNA damage-induced senescence, we observed a similar phenotype upon CDK4/6 inhibition in breast cancer cells. We used RNA sequencing to investigate the gene expression profile of MCF7 cells upon CDK4/6 inhibition five days after exposure.
Published in
The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence
Schmidt A, Allmann S, Schwarzenbach C et al. · Nucleic acids research 2024 · PMID 38783095 · doi:10.1093/nar/gkae426
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Also filed as BioProject PRJNA985731 and SRA study SRP445109. Searching any of these in the dataset finder brings you back here.

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