Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation
DNA methylation · human · 20 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 3 × MDA-MB-468, Uta, Day 10, vs 3 × MDA-MB-468, NOa, Day 10, vs 3 × MDA-MB-231, Uta, Day 10, vs 3 × MDA-MB-231, NOa, Day 10,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE236272_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA989601 and SRA study SRP446809. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7526949 MDA-MB-468, Uta, Day 10, 1 MDA-MB-468, Uta, Day 10,
- GSM7526950 MDA-MB-468, Uta, Day 10, 2 MDA-MB-468, Uta, Day 10,
- GSM7526951 MDA-MB-468, Uta, Day 10, 3 MDA-MB-468, Uta, Day 10,
- GSM7526952 MDA-MB-468, NOa, Day 10, 1 MDA-MB-468, NOa, Day 10,
- GSM7526953 MDA-MB-468, NOa, Day 10, 2 MDA-MB-468, NOa, Day 10,
- GSM7526955 MDA-MB-468, NOa, Day 10, 3 MDA-MB-468, NOa, Day 10,
- GSM7526962 MDA-MB-231, Uta, Day 10, 1 MDA-MB-231, Uta, Day 10,
- GSM7526964 MDA-MB-231, Uta, Day 10, 2 MDA-MB-231, Uta, Day 10,
- GSM7526965 MDA-MB-231, Uta, Day 10, 3 MDA-MB-231, Uta, Day 10,
- GSM7526966 MDA-MB-231, NOa, Day 10, 1 MDA-MB-231, NOa, Day 10,
- GSM7526967 MDA-MB-231, NOa, Day 10, 2 MDA-MB-231, NOa, Day 10,
- GSM7526968 MDA-MB-231, NOa, Day 10, 3 MDA-MB-231, NOa, Day 10,
- GSM7526972 MDA-MB-231, Uta, Day 10, INP
- GSM7526974 MDA-MB-231, Uta, Day 10, m6A
- GSM7526975 MDA-MB-231, Utb, Day 10, INP
- GSM7526976 MDA-MB-231, Utb, Day 10, m6A
- GSM7526977 MDA-MB-231, NOa, Day 10, INP
- GSM7526978 MDA-MB-231, NOa, Day 10, m6A
- GSM7526980 MDA-MB-231, NOb, Day 10, INP
- GSM7526981 MDA-MB-231, NOb, Day 10, m6A
- GSE279022 RNA N6-Methyladenosine (m6A) regulates cell cycle progression in Diffuse Midline Glioma (DMG) and confers sensitivity to FTO inhibition 30 samples shares fto, n6-methyladenosine, regulate
- GSE300200 The Lysine Demethylase Kdm4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma 26 samples shares demethylase, activity, regulate
- GSE228608 Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48 28 samples shares fto, demethylase
- GSE228606 Recruitment of the m6A/Am demethylase FTO to target RNAs by the telomeric zinc finger protein ZBTB48 [RNA-seq] 4 samples shares fto, demethylase
- GSE298598 METTL3/YTHDF2 axis inhibits cell proliferation and fibrosis by degrading the N6-methyladenosine modification of TCF7L2-Smad2/Smad3 mRNA in pterygium 12 samples shares n6-methyladenosine, inhibits
- GSE256353 Upregulated cholesterol biosynthesis facilitates the survival of methylation-retaining AML cells following decitabine treatment [single_colony_TEM-Seq] 1728 samples shares methylation, regulate
- GSE303967 DNA methylation and transcriptomic profiles of Wilms tumour reveal new deregulated genes and epigenetic processes relevant for tumour stratification and management 45 samples shares methylation, regulate
- GSE194281 The KDM1A and KDM7A lysine demethylases cooperate to regulate androgen receptor function in prostate cancer cells 30 samples shares demethylase, regulate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.