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Expression profiling of METTL14 depleted human pancreatic β-like cells

GSE236323 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2024/06/13 Platform GPL24676
Summary
N6-methyladenosine (m6A) is the most abundant chemical modification in mRNA, and plays important roles in human embryonic stem cell pluripotency, maintenance, and differentiation. However, the role of m6A and the precise mechanisms involved during the development of β-cells are unexplored. Here, we explored the requirement of METTL14-mediated m6A RNA methylome in human pancreatic β-like cells by simultaneously inducing METTL14 knockdown in H1 human embryonic stem cells (hESCs) with doxycycline (Dox) treatment and differentiating hESCs towards pancreatic β-like cells in vitro.
Published in
m(6)A mRNA methylation by METTL14 regulates early pancreatic cell differentiation
Kahraman S, De Jesus DF, Wei J et al. · The EMBO journal 2024 · PMID 39322760 · doi:10.1038/s44318-024-00213-2
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Also filed as BioProject PRJNA990567 and SRA study SRP447051. Searching any of these in the dataset finder brings you back here.

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