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Astrocytic heterogeneous nuclear ribonucleoprotein U facilitates scar formation after spinal cord injury

GSE236433 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/28 Platform GPL24676
Summary
In this study, by a genome-wide RNA interference screen, we identified heterogeneous nuclear ribonucleoprotein U (Hnrnpu) as an endogenous key molecule in astrocyte activation. Inhibition of Hnrnpu in astrocytes impairs the formation of astrocytic glial scar, motor function recovery, and neuronal regeneration after spinal cord injury (SCI) in mice. Therefore, we then performed gene expression profiling analysis to evalute the function of HNRNPU in human astrocytes. Our findings uncover that modulation of endogenous astrocytic function through Hnrnpu would be a promising therapeutic avenue to restore neurological function after the injury.
Published in
Astrocytic heterogeneous nuclear ribonucleoprotein U is involved in scar formation after spinal cord injury
Quan L, Uyeda A, Manabe I et al. · Journal of neuroinflammation 2025 · PMID 39891176 · doi:10.1186/s12974-025-03351-4
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Also filed as BioProject PRJNA990796 and SRA study SRP447180. Searching any of these in the dataset finder brings you back here.

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